The role of the RNAi/Dicer/Ago system in degrading RNA viruses has been elusive in mammals in the past, which has prompted authors to think that interferon (IFN) synthesis is essential in this clade, relegating the RNAi defense strategy against viral …
Perfect annealing between microRNAs (miRNAs) and messenger RNAs (mRNAs) was computationally searched at a broad scale in the human genome to determine whether theoretical pairing is restrictively represented in functional subnetworks or is randomly …
Directed acyclic graphs (DAGs) are used in many domains ranging from computer science to bioinformatics, including industry and geoscience. They enable to model complex evolutions where spatial objects (e.g., soil erosion)maymove, (dis)appear,merge …
The role of the RNAi/Dicer/Ago system to degrade RNA viruses has been elusive in mammals,which prompted authors to think that interferon (IFN) synthesis is essential in this clade relegatingthe RNAi defense strategy against viral infection as …
RNA interference (RNAi) refers to a conserved posttranscriptional mechanism for the degradation of RNA by short dsRNAs. A genome-wide analysis of mRNAs that are complementary to RNAs of variable length that are transcribed from the full transcriptome …
MicroRNAs, small non-coding elements implied in gene regulation, are very interesting biomarkers for various diseases such as cancers. They represent potential prodigious biotechnologies for early diagnosis and gene therapies. However, experimental …
Double-stranded DNA is able to form triple-helical structures by accommodating a third nucleotide strand. A nucleic acid triplex occurs according to Hoogsteen rules that predict the stability and affinity of the third strand bound to the Watson-Crick …
Attributed directed graphs are directed graphs in which nodes are associated with sets of attributes. Many data from the real world can be naturally represented by this type of structure, but few algorithms are able to directly handle these complex …
MicroRNAs play critical roles in many physiological processes. Their dysregulations are also closely related to the development and progression of various human diseases, including cancer. Therefore, identifying new microRNAs that are associated with …
Frequent pattern mining is an important data mining task with a broad range of applications. Initially focused on the discovery of frequent itemsets, studies were extended to mine structural forms like sequences, trees or graphs. In this paper, we …